Jul 2022 – Nov 2022
Therapeutic Potential and Commercial Analysis of GPR139 Agonists for Parkinson’s Disease
Project Lead
Background: Addressed unmet clinical needs in Parkinson’s disease by exploring GPR139 agonists as a new therapeutic target.
Research Content:
• Validated efficacy by testing the effects of GPR139 agonists on neurotransmitter release and motor function improvement in Parkinson’s mouse models.
• Combined market demand and competitor analysis to evaluate the commercial potential of the drug.
Mar 2022 – Jun 2022
Effects of PDE3 and PDE5 Inhibitors on Rat Thoracic Aorta Relaxation
Project Lead
Background: Studied vascular smooth muscle relaxation to analyze the pharmacological effects of PDE3 and PDE5 inhibitors (Milrinone and Sildenafil) for drug development.
Research Content:
• Evaluated relaxation efficacy through ex vivo thoracic aorta ring experiments.
• Compared the regulatory effects of the two inhibitors on cAMP and cGMP signaling pathways to analyze mechanisms of action.